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Vascular Endothelial Growth Factor-A and Platelet-Derived Growth Factor-B Combination Gene Therapy Prolongs Angiogenic Effects via Recruitment of Interstitial Mononuclear Cells and Paracrine Effects Rather Than Improved Pericyte Coverage of...

Authors :
Korpisalo, Petra
Karvinen, Henna
Rissanen, Tuomas T.
Kilpijoki, Johanna
Marjomäki, Varpu
Baluk, Peter
McDonald, Donald M.
Yihai Cao
Eriksson, Ulf
Alitalo, Kari
YIä-Herttuala, Seppo
Source :
Circulation Research; 11/7/2008, Vol. 103 Issue 10, p1092-1099, 8p, 5 Graphs
Publication Year :
2008

Abstract

The article presents a discussion concerning a study on the vascular endothelial growth factor-A and platelet-derived growth factor-B combination gene therapy that prolongs the effects of angiogenic via recruitment of interstitial in the United States. The advantages of combination gene therapy are discussed. It also concludes that the combination of AdVEGF-A and AdPDGF-B intramuscular delivery causes prolonged angiogenic response.

Details

Language :
English
ISSN :
00097330
Volume :
103
Issue :
10
Database :
Supplemental Index
Journal :
Circulation Research
Publication Type :
Academic Journal
Accession number :
35396127
Full Text :
https://doi.org/10.1161/CIRCRESAHA.108.182287