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Prevalence of Nevirapine-Associated Resistance Mutations after Single Dose Prophylactic Treatment among Antenatal Clinic Attendees in North Rift Kenya.

Authors :
Michael Kiptoo
Hiroshi Ichimura
Raphael L. Wembe
Zipporah Ng'Ang'a
Jones Mueke
Joyceline Kinyua
Nancy Lagat
Fredrick Okoth
E.M. Songok
Source :
AIDS Research & Human Retroviruses; Dec2008, Vol. 24 Issue 12, p1555-1559, 5p
Publication Year :
2008

Abstract

AbstractThe use of single dose nevirapine to prevent mother-to-child transmission of HIV has been reported to induce drug-resistant mutations and reduce options for antiretroviral treatment for HIV-infected mothers and their children. To explore the status of nevirapine-resistant HIV genotypes in rural hospitals in the North Rift Valley Province of Kenya, samples collected 3 months after single dose nevirapine from 36 mothers and their children were analyzed. Resistance mutations were genotypically evaluated through proviral DNA amplification, cloning, and sequencing. Ten mothers (27.8) had antiretroviral-associated resistance mutations of whom four (11.1) had specific nevirapine (NNRTI) resistance-associated mutations. Three mothers (8.3) transmitted the infection to their infants. This presence of nevirapine mutations in rural antenatal clinic attendees confirms the importance of integrating antiretroviral resistance monitoring as a key component in programs geared to prevention of HIV mother-to-child transmission. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
08892229
Volume :
24
Issue :
12
Database :
Supplemental Index
Journal :
AIDS Research & Human Retroviruses
Publication Type :
Academic Journal
Accession number :
35836701
Full Text :
https://doi.org/10.1089/aid.2008.0018