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Prevalence of Nevirapine-Associated Resistance Mutations after Single Dose Prophylactic Treatment among Antenatal Clinic Attendees in North Rift Kenya.
- Source :
- AIDS Research & Human Retroviruses; Dec2008, Vol. 24 Issue 12, p1555-1559, 5p
- Publication Year :
- 2008
-
Abstract
- AbstractThe use of single dose nevirapine to prevent mother-to-child transmission of HIV has been reported to induce drug-resistant mutations and reduce options for antiretroviral treatment for HIV-infected mothers and their children. To explore the status of nevirapine-resistant HIV genotypes in rural hospitals in the North Rift Valley Province of Kenya, samples collected 3 months after single dose nevirapine from 36 mothers and their children were analyzed. Resistance mutations were genotypically evaluated through proviral DNA amplification, cloning, and sequencing. Ten mothers (27.8) had antiretroviral-associated resistance mutations of whom four (11.1) had specific nevirapine (NNRTI) resistance-associated mutations. Three mothers (8.3) transmitted the infection to their infants. This presence of nevirapine mutations in rural antenatal clinic attendees confirms the importance of integrating antiretroviral resistance monitoring as a key component in programs geared to prevention of HIV mother-to-child transmission. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 08892229
- Volume :
- 24
- Issue :
- 12
- Database :
- Supplemental Index
- Journal :
- AIDS Research & Human Retroviruses
- Publication Type :
- Academic Journal
- Accession number :
- 35836701
- Full Text :
- https://doi.org/10.1089/aid.2008.0018