Two Estrogen-Related Variants in CYP19A1 and Endometrial Cancer Risk: A Pooled Analysis in the Epidemiology of Endometrial Cancer Consortium.

The article presents a pooled analysis which tests the hypothesis whether the presence of one or both A alleles in the single nucleotide polymorphisms (SNP) results in an increased endometrial cancer risk. It notes that common CYP19A1 variants are linked with the 10% to 20% increase in the levels of circulating estrogen in postmenopausal women. It analyzes 4,998 endometrial cancer cases and 8,285 controls for ten studies in the Epidemiology of Endometrial Cancer Consortium.