Reversible Oxidative Modification: A Key Mechanism of Na+-K+ Pump Regulation.

Authors :: Figtree, Gemma A.
Chia-Chi Liu
Bibert, Stephanie
Hamilton, Elisha J.
Garcia, Alvaro
White, Caroline N.
Chia, Karin K. M.
Cornelius, Flemming
Geering, Kaethi
Rasmussen, Helge H.
Source :: Circulation Research; 7/17/2009, Vol. 105 Issue 2, p185-193, 9p, 8 Graphs
Publication Year :: 2009
Abstract: The article presents a study which examines whether angiotensin II whether this is mediated by oxidative modification of the pump subunits. Result shows that increased in glutathionylation was associated with decreased α1/β1 subunit coimmunoprecipitation. Researchers concluded that pathophysiological conditions characterized by neurohormonal dysregulation, myocardial oxidative stress and raised myocyte sodium levels.