Angiomotin-Like Protein 1 Controls Endothelial Polarity and Junction Stability During Sprouting Angiogenesis.

Authors :: Yujuan Zheng
Vertuani, Simona
Nyström, Staffan
Audebert, Stéphane
Meijer, Inëz
Tegnebratt, Tetyana
Borg, Jean-Paul
Uhlén, Per
Majumdar, Arindam
Holmgren, Lars
Source :: Circulation Research; 7/31/2009, Vol. 105 Issue 3, p260-270, 11p, 4 Graphs
Publication Year :: 2009
Abstract: The article presents a study which identifies the function of angiomotin-like protein 1 (AmotL1) in comparison to angiomotin (Amot) in the polarization and migration of endothelial cell (EC). It states that (Amot) is a coiled-coil protein in ECs which controls migration, formation of tight junction (TJ) and cell polarity. Results of the small interfering ribonucleic acid-(RNA) mediated silencing in mouse cells show that AmotL1 has the same effects with Amot on EC migration and TJ formation.

Subjects :: CELL polarity
CELL migration
ENDOTHELIUM
TIGHT junctions
SMALL interfering RNA
LABORATORY mice

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