Urotensin II Receptor Knockout Mice on an ApoE Knockout Background Fed a High-Fat Diet Exhibit an Enhanced Hyperlipidemic and Atherosclerotic Phenotype.

Authors :: Bousette, Nicolas
D'Orleans-Juste, Pedro
Kiss, Robert S.
Zhipeng You
Genest, Jacques
Al-Ramli, Wisam
Qureshi, Salman T.
Gramolini, Anthony
Behm, David
Ohlstein, Eliot H.
Harrison, Stephen M.
Douglas, Stephen A.
Giaid, Adel
Source :: Circulation Research; 9/25/2009, Vol. 105 Issue 7, p686-695, 10p, 8 Graphs
Publication Year :: 2009
Abstract: The article examines the effect of Urotensin II (UII) receptor (UT) gene deletion in the atherosclerosis of a mouse. According to the article, UT gene deletion in an apolipoprotein E (ApoE)-deficient background boosts downregulation of acyl-coenzyme A cholesterol acyltransferase (ACAT1). In result, it weaken hepatic lipoprotein receptor-mediated uptake and lipid transporter expression.

Subjects :: MEDICAL research
ANIMAL experimentation
LABORATORY mice
ATHEROSCLEROSIS
APOLIPOPROTEIN E
GENE expression

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