SCN5A Mutations and the Role of Genetic Background in the Pathophysiology of Brugada Syndrome.

The article presents a study of the role of genetic background in pathophysiology of Brugada Syndrome (BrS) which affects mutations in the SCN5A. BrS is an inherited arrhythmia syndrome with an increased risk of sudden death, resulting from polymorphic ventricular tachycardia and ventricular fibrillation in the absence of gross structural abnormalities. According to the study, BrS is not directly caused by mutations in SCN5A, which complicated further the already complex relationship between the two.