Back to Search
Start Over
058 Effect of Cyclosporine on Left Ventricle Remodeling after Reperfused Myocardial Infarction.
- Source :
- Archives of Cardiovascular Diseases Supplements; Jan2010, Vol. 2 Issue 1, p19-19, 1p
- Publication Year :
- 2010
-
Abstract
- Objective: This study examined the effect of cyclosporine A used at the time of reperfusion, on LV remodeling and function by cardiac magnetic resonance (CMR) in the early days and several months after AMI. Background: In a human study, administration of cyclosporine A at the time of acute myocardial infarction (AMI) reperfusion was associated with a smaller infarct size. However, experimental data suggest that cyclosporine A has a detrimental effect on left ventricular remodeling. Methods: 28 patients of the original cyclosporine A study had an acute (day 5) and a follow-up (6 months) CMR study. Cine imaging was used to determine LV volumes, mass, ejection fraction and myocardial wall thickness in infarcted and remote non-infarcted myocardium, and late gadolinium imaging was used to determine infarct size. Results: There was a persistent reduction of the absolute infarct size at 6 months in the cyclosporine A group compared with the control group of patients (29±15 grams VS 38±14 grams; P=0.04). There was a significant reduction of LV end-systolic volume (and a trend for LV end-diastolic volume; P=0.07) in the cyclosporine A group, compared with the control group, both at day 5 and at 6 months after infarction. There was no significant difference between the two groups in either global LV mass or regional wall thickness of the remote non-infarcted myocardium at day 5 or at 6 months. Attenuation of LV dilatation and improvement of LV ejection fraction by cyclosporine A at 6 months were correlated with infarct size reduction. Conclusion: Cyclosporine A used at the moment of AMI reperfusion persistently reduces infarct size and does not have a detrimental effect on LV remodeling [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 18786480
- Volume :
- 2
- Issue :
- 1
- Database :
- Supplemental Index
- Journal :
- Archives of Cardiovascular Diseases Supplements
- Publication Type :
- Academic Journal
- Accession number :
- 48985007
- Full Text :
- https://doi.org/10.1016/S1878-6480(10)70060-4