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058 Effect of Cyclosporine on Left Ventricle Remodeling after Reperfused Myocardial Infarction.

Authors :
Mewton, Nathan
Croisille, Pierre
Gahide, Gerald
Rioufol, Gilles
Bonnefoy, Eric
Sanchez, Ingrid
Tri Cung, Thien
Sportouch, Catherine
Angoulvant, Denis
Finet, Gérard
André-Fouët, Xavier
Derumeaux, Geneviève
Piot, Christophe
Vernhet, Hélène
Revel, Didier
Ovize, Michel
Source :
Archives of Cardiovascular Diseases Supplements; Jan2010, Vol. 2 Issue 1, p19-19, 1p
Publication Year :
2010

Abstract

Objective: This study examined the effect of cyclosporine A used at the time of reperfusion, on LV remodeling and function by cardiac magnetic resonance (CMR) in the early days and several months after AMI. Background: In a human study, administration of cyclosporine A at the time of acute myocardial infarction (AMI) reperfusion was associated with a smaller infarct size. However, experimental data suggest that cyclosporine A has a detrimental effect on left ventricular remodeling. Methods: 28 patients of the original cyclosporine A study had an acute (day 5) and a follow-up (6 months) CMR study. Cine imaging was used to determine LV volumes, mass, ejection fraction and myocardial wall thickness in infarcted and remote non-infarcted myocardium, and late gadolinium imaging was used to determine infarct size. Results: There was a persistent reduction of the absolute infarct size at 6 months in the cyclosporine A group compared with the control group of patients (29±15 grams VS 38±14 grams; P=0.04). There was a significant reduction of LV end-systolic volume (and a trend for LV end-diastolic volume; P=0.07) in the cyclosporine A group, compared with the control group, both at day 5 and at 6 months after infarction. There was no significant difference between the two groups in either global LV mass or regional wall thickness of the remote non-infarcted myocardium at day 5 or at 6 months. Attenuation of LV dilatation and improvement of LV ejection fraction by cyclosporine A at 6 months were correlated with infarct size reduction. Conclusion: Cyclosporine A used at the moment of AMI reperfusion persistently reduces infarct size and does not have a detrimental effect on LV remodeling [Copyright &y& Elsevier]

Details

Language :
English
ISSN :
18786480
Volume :
2
Issue :
1
Database :
Supplemental Index
Journal :
Archives of Cardiovascular Diseases Supplements
Publication Type :
Academic Journal
Accession number :
48985007
Full Text :
https://doi.org/10.1016/S1878-6480(10)70060-4