Coenzyme Q10: Immunomodulation Effects.

In this in vitro study involving human peripheral blood mononuclear cells (PBMC) from 19 volunteers that was incubated for 24 hours with or without coenzyme Q10 (in different doses - 0.6, 1.25, 2.5, 5.0 muM), significant decreases in TNF-alpha secretion were associated with 0.6 and 1.25 muM coenzyme Q10, and significant inhibition of IL-2 secretion was associated with increasing doses of coenzyme Q10. No significant effects on production of the proinflammatory cytyokines, IL-1beta, IL-6, IFN-gamma, and anti-inflammatory cytokines IL-1ra and IL-10 were found. The authors conclude, "The results suggest that CoQ10 exerts a certain effect on cytokine production by PBMC related to its capacity to modulate human immune function." [ABSTRACT FROM AUTHOR]