In Vivo Low-Intensity Pulsed Ultrasound (LIPUS) Following Tendon Injury Promotes Repair During Granulation but Suppresses Decorin and Biglycan Expression During Remodeling.

The article presents a study which examined if low intensity pulsed ultrasound (LIPUS) effects on matrix synthesis change at various stages of tendon healing. Based on results, a single sonication of LIPUS increased collagen type COL1A1 and COL3A1 messenger Ribonucleic Acid (mRNA) in healing patellar tendons on application on the fourth or 14th day following injury, but not on the 28th day. It is stated that to promote tendon healing, LIPUS should be administered during the granulation phase and not during the remodeling phase.