Back to Search
Start Over
Synthesis and characterization of mesoporous Gd2O3 nanotube and its use as a drug-carrying vehicle.
- Source :
- Acta Biomaterialia; Sep2010, Vol. 6 Issue 9, p3713-3719, 7p
- Publication Year :
- 2010
-
Abstract
- Abstract: Gd<subscript>2</subscript>O<subscript>3</subscript> nanotubes were constructed for the first time by assembling highly crystalline Gd<subscript>2</subscript>O<subscript>3</subscript> nanoparticles through the use of combined soft template and sol–gel methods. Amphiphilic block copolymer was used as structure-directing agent and gadolinium isopropoxide as inorganic precursor in non-aqueous solution. The amphiphilic copolymer molecules are known to undergo self-organization above a critical micelle concentration, forming micellular architecture that further provides a structurally ordered active site for the nucleation and growth of Gd monomers. The resulting self-assembly of the Gd<subscript>2</subscript>O<subscript>3</subscript> nanocrystals led to the formation of Gd<subscript>2</subscript>O<subscript>3</subscript> tubular nanostructure after pyrolytic removal of the template. Transmission electron microscopy analysis indicated a mesoporous channel array along the [110] direction of the nanotubes where the wall of nanotube is well organized by the assembly of a highly crystalline framework of Gd<subscript>2</subscript>O<subscript>3</subscript> nanocrystals. This Gd<subscript>2</subscript>O<subscript>3</subscript> nanotube exhibited weak superparamagnetic property and was found to be able to carry and elute a model molecule, i.e. ibuprofen (IBU), in a controllable manner via an external magnetic field. The mechanism of IBU release from the nanotubes with and without the use of magnetic stimulus was proposed. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 17427061
- Volume :
- 6
- Issue :
- 9
- Database :
- Supplemental Index
- Journal :
- Acta Biomaterialia
- Publication Type :
- Academic Journal
- Accession number :
- 52579037
- Full Text :
- https://doi.org/10.1016/j.actbio.2010.03.009