Histone Deacetylase 3 Antagonizes Aspirin-Stimulated Endothelial Nitric Oxide Production by Reversing Aspirin-Induced Lysine Acetylation of Endothelial Nitric Oxide Synthase.

The article discusses research on the role of lysine acetylation of endothelial nitric oxide synthase (eNOS) in regulating endothelial nitric oxide (NO) production through a low aspirin dosage. The study examined whether lysine deacetylase histone deacetylase (HDAC)3 can antagonize the effect of low-dose aspirin on endothelial NO production through a reversed acetylation of eNOS lysine residues. The study showed the increase in bioavailable vascular NO with induced low-dose aspirin in vivo.