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Association between HLA-B*1502 allele and carbamazepine-induced severe cutaneous adverse reactions in Han people of southern China mainland.
- Source :
- Seizure; Jul2011, Vol. 20 Issue 6, p446-448, 3p
- Publication Year :
- 2011
-
Abstract
- Abstract: Previous studies have found a strong association between HLA-B*1502 and carbamazepine-induced Stevens–Johnson syndrome in Asian areas including Taiwan, Hongkong and Thailand. This study explores the association between HLA-B*1502 allele and carbamazepine-induced cutaneous adverse reactions in Han Chinese of southern China mainland, and find the genetic marker that can predict carbamazepine-induced cutaneous adverse reactions. HLA-B*1502 allele genotyping was performed by a polymerase chain reaction–sequence specific primers (PCR–SSP) method in 48 Han Chinese subjects who had carbamazepine-induced cutaneous adverse reactions, including 9 severe cutaneous adverse reaction patients with Stevens–Johnson syndrome (SJS) or toxic epidermal necrolysis (TEN) and 39 cutaneous adverse reaction patients with maculopapular eruption (MPE). Meanwhile 80 carbamazepine-tolerant controls and 62 healthy individuals were also tested. The frequency of HLA-B*1502 allele among SJS/TEN patients (100%) is significantly higher than carbamazepine-tolerant controls (13.75%, P <0.001) and healthy individuals (17.74%, P <0.001). But the frequency between MPE patients and carbamazepine-tolerant controls (25.64% vs.13.75%, P =0.110) did not have any significant difference. The data showed that HLA-B*1502 allele is strongly associated with carbamazepine-induced SJS/TEN but not MPE in Han Chinese of southern China mainland. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 10591311
- Volume :
- 20
- Issue :
- 6
- Database :
- Supplemental Index
- Journal :
- Seizure
- Publication Type :
- Academic Journal
- Accession number :
- 61248716
- Full Text :
- https://doi.org/10.1016/j.seizure.2011.02.003