Isolation and Identification of FR198248, a Hydroxylated 1,3-Dihydroisobenzofuran, from Aspergillus flavipes as an Inhibitor of Peptide Deformylase.

The article presents a study on the identification and isolation of a hydroxylated 1,3-dihydroisobenzofuran, FR198248, from Aspergillus flavipes as an inhibitor of peptide deformylase (PDF). The study showed that PDF inhibitors have acted as broad-spectrum antibacterial agents. It concludes that 1,3-dihydroisobenzofurans are highly hydroxylated and showed moderate antibacterial activity against Staphylococus aureus.