Immunohistochemical Detection of Phosphatidylserine and Thrombospondin on Denucleating Erythroblasts in Rat Bone Marrow.

The article presents an immunohistochemical analysis of phosphatidylserine and thrombospondin on denucleating erythroblasts in rat bone marrow. It says the immunohistological detection of both phosphatidylserine and thrombospondin as phagocytosis-inducing factors in general apoptotic events has confirmed the hypothesis about some roles being played by apoptotic factors in the denucleation of erythroblasts. It notes the detection of both of these factors on the surface of cell membrane of mature erythroblasts, while thrombospondin was also present in more immature erythroblasts. It cites the restriction of the positivities of both on the surface of the cell membrane that encloses the protruding nuclei, during denucleation.