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Total Synthesis and Anti-leishmanial Activity of Some Curcumin Analogues.
- Source :
- Drug Research / Arzneimittel-Forschung (Editio Cantor Verlag fur Medizin und Naturwissenschaften); Sep2002, Vol. 52 Issue 9, p695, 4p
- Publication Year :
- 2002
-
Abstract
- Curcumin (1) an important yellow dye isolated from Curcuma longa rhizomes, exhibits a variety of pharmacological effects such as anti-inflammatory, antioxidant and antiviral activity. Ten curcuminoids (2-11) were synthesized by the condensation of 2,4-pentanedione with differently substituted benzaldehydes, using the boron complex approach, which avoided Knoevenagel condensation at C-3 of the diketone. The curcuminoids were assayed in vitro against Leishmania amazonensis promastigotes using pentamidine isethionate (CAS 140-64-7) as the reference drug. Compound (5) 1,7-bis-(2hydroxy-4-methoxyphenyl)-1,6heptadiene-3,5-dione) was the most effective. [ABSTRACT FROM AUTHOR]
- Subjects :
- TURMERIC
PHARMACOKINETICS
Subjects
Details
- Language :
- English
- ISSN :
- 00044172
- Volume :
- 52
- Issue :
- 9
- Database :
- Supplemental Index
- Journal :
- Drug Research / Arzneimittel-Forschung (Editio Cantor Verlag fur Medizin und Naturwissenschaften)
- Publication Type :
- Academic Journal
- Accession number :
- 7361098