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Liver Enzymes Concentrations Are Closely Related to Prediabetes: Findings of the Shanghai Diabetes Study II (SHDS II).
- Source :
- Biomedical & Environmental Sciences; Feb2012, Vol. 25 Issue 1, p30-37, 8p
- Publication Year :
- 2012
-
Abstract
- Abstract: Objective: To investigate the relationship of liver enzymes with hyperglycemia in a large population in Shanghai and identify the association between liver enzymes and insulin resistance. Methods: A total of 3 756 participants were enrolled. Each participant underwent an oral glucose tolerance test and completed a questionnaire. Anthropometric indices were recorded and serum samples were collected for measurement. Results: Liver enzymes concentrations were independently associated with i-IGT, IFG+IGT, and diabetes. With the increase of ALT and GGT concentrations, ORs for i-IGT, IFG+IGT, and diabetes increased gradually. By comparing patients in the highest quartile of GGT concentrations or ALT concentrations with those in the lowest quartile (Q1), ORs for i-IGT, IFG+IGT, or diabetes was significant after adjustment. Both ALT and GGT concentrations were linearly correlated with HOMA-IR and independently associated with HOMA-IR [ALT OR (95% CI): 2.56 (1.51-4.34) P=0.00; GGT OR (95% CI): 2.66 (1.53-4.65) P=0.00]. Conclusion: Serum ALT and GGT concentrations were closely related to pre-diabetes and diabetes in the Shanghai population and positively associated with insulin resistance. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 08953988
- Volume :
- 25
- Issue :
- 1
- Database :
- Supplemental Index
- Journal :
- Biomedical & Environmental Sciences
- Publication Type :
- Academic Journal
- Accession number :
- 73768820
- Full Text :
- https://doi.org/10.3967/0895-3988.2012.01.005