Complex Trait Analysis of Ventricular Septal Defects Caused by Nkx2-5 Mutation.

The article sets to provide a more nuanced understanding of congenital heart disease (CHD) since the evidence of it having a multifactorial basis is indirect. The factors that modify rather than cause CHD substantially affect risk in predisposed individuals. Their characterization in a mouse model offers the potential to narrow the search space in human studies and develop alternative strategies for prevention.