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Role of EGFR Mutation Status in Patients with Stage III Non-squamous Non-small Cell Lung Cancer Treated with Chemoradiotherapy.
- Source :
- Chinese Journal of Lung Cancer; Sep2011, Vol. 14 Issue 9, p715-718, 4p, 2 Charts, 1 Graph
- Publication Year :
- 2011
-
Abstract
- Background and objective The presence of epidermal growth factor receptor (EGFR) mutations is predictive of a better response to EGFR tyrosine kinase inhibitors (EGFR-TKIs) and initial chemotherapy in advanced non-squamous non-small cell lung cancer (NSCLC). The aim of this study is to analyze the association between the EGFR mutations and the outcome of combined chemoradiotherapy in stage III non-squamous NSCLC. Methods Patients with stage III non-squamous NSCLC whose EGFR mutation status had been identified were retrospectively analyzed. The response of 87 patients to combined chemoradiotherapy, the two-year survival rate, and the response of 128 patients to initial chemotherapy were evaluated. Results The response rate to combined chemoradiotherapy was 84.6% (33/39) in EGFR mutation-positive patients, significantly higher than the 56.3% (27/48) response rate in EGFR mutation- negative patients (P=0.004). Two-year survival rates were 53.8% and 50% in EGFR mutation-positive and mutation-negative patients, respectively. There was no significant difference in the overall survival for both patient groups. The overall response rate to initial chemotherapy was 34.5% (19/55) in EGFR mutation-positive patients, compared with the 21.9% (16/73) response rate in EGFR mutation-negative patients. Conclusion EGFR mutation-positive status can predict better response to combined chemoradiotherapy, but is not associated with overall survival in patients with stage III non-squamous NSCLC. [ABSTRACT FROM AUTHOR]
- Subjects :
- LUNG cancer treatment
LUNG cancer prognosis
CELL receptors
COMBINED modality therapy
EPIDERMAL growth factor
LUNG cancer
GENETIC mutation
HEALTH outcome assessment
RESEARCH funding
SURVIVAL
TREATMENT effectiveness
RETROSPECTIVE studies
DATA analysis software
DESCRIPTIVE statistics
KAPLAN-Meier estimator
Subjects
Details
- Language :
- Chinese
- ISSN :
- 10093419
- Volume :
- 14
- Issue :
- 9
- Database :
- Supplemental Index
- Journal :
- Chinese Journal of Lung Cancer
- Publication Type :
- Academic Journal
- Accession number :
- 80179904