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Decrease of Intracellular Chloride Concentration Promotes Endothelial Cell Inflammation by Activating Nuclear Factor-κB Pathway.
- Source :
- Hypertension (0194911X); Nov2012, Vol. 60 Issue 5, p1287-1293, 7p
- Publication Year :
- 2012
-
Abstract
- The article examines the mechanism explaining how CIC-3 modulates NF-KB signaling. Evidence suggested that CIC-3 channel/antiporter is involved in regulation of NF-KB activation. It is hypothesized that CIC-3-dependent alteration of intracellular chloride concentration underlies the effect of CIC-3 on NF-KB activity in endothelial cells.
Details
- Language :
- English
- ISSN :
- 0194911X
- Volume :
- 60
- Issue :
- 5
- Database :
- Supplemental Index
- Journal :
- Hypertension (0194911X)
- Publication Type :
- Academic Journal
- Accession number :
- 82857914
- Full Text :
- https://doi.org/10.1161/HYPERTENSIONAHA.112.198648