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Does selective serotonin reuptake inhibitor (SSRI) fluoxetine affects mussel Mytilus galloprovincialis?
- Source :
- Environmental Pollution; Feb2013, Vol. 173, p200-209, 10p
- Publication Year :
- 2013
-
Abstract
- Fluoxetine (FLX) the active pharmaceutical ingredient (API) in Prozac<superscript>®</superscript> is a widely prescribed psychoactive drug which ubiquitous occurrence in the aquatic environment is associated to a poor removal rate in waste-water treatment plant (WWTP) systems. This API acts as a selective serotonin reuptake inhibitor (SSRI) frequently reported to cause disrupting effects in non-target species. The objective of this study includes a multibiomarker response evaluation on mussel Mytilus galloprovincialis during two weeks exposure to 75 ng L<superscript>−1</superscript> FLX assessing antioxidant enzymes activities – superoxide dismutase (SOD), catalase (CAT) and glutathione-S-transferase (GST); lipid peroxidation (LPO), acetylcholinesterase (AChE) neurotoxic response and endocrine disruption through alkali-labile phosphates (ALP) indirect measurement of vitellogenin-like proteins. Results show transient tissue-specific enzymatic responses and damage affecting mostly mussel gills. However, the clear ALP levels inhibition throughout time in both sex-differentiated gonads gives evidence to FLX reinforced action as an endocrine disruptor rather than an oxidative or neurotoxic inducer. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 02697491
- Volume :
- 173
- Database :
- Supplemental Index
- Journal :
- Environmental Pollution
- Publication Type :
- Academic Journal
- Accession number :
- 84366605
- Full Text :
- https://doi.org/10.1016/j.envpol.2012.10.018