Inhibition of Toll-Like Receptor 2-Mediated NF-κB Activation in Vero Cells with Herpesvirus of Turkeys.

The article offers information on the study that constructed and transfected vectors for chicken Toll-like receptor 1 and 2 expression into Vero cells. HVT infection reveals nuclear factor kappa light-chain enhancer of activated B cell activation. Vero cells transfected with chTLRI-1,chTLR1-2, or both, shows NF-kB activation inhibited by herpesvirus of turkeys (HVT). HVT's role in activating TLR2 signaling and chTLR1 in TLR2 subfamily-mediated NF-kB inhibition after HVT infection is demonstrated.