Bioactivity-guided fractionation of the stem bark extract of Pterocarpus dalbergioides Roxb. ex Dc growing in Egypt.

Abstract: A bioactivity-guided investigation of the ethanolic extract (70%) of the stem bark of Pterocarpus dalbergioides Roxb. ex DC revealed that the butanol fraction possessed potent antihyperglycemic and anti-inflammatory activities at a dose of 100mg/kg b.wt. compared to metformin (150mg/kg b.wt.) and indomethacin (20mg/kg b.wt.) respectively. Two phenolic acids viz: gentisic (1) and gallic (3) acids and isoflavone genistin (2) were isolated for the first time from the studied plant adopting a bioactivity-guided fractionation. Identification of the isolated compounds was achieved using physical, chemical and spectroscopic data. [Copyright &y& Elsevier]