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Suppression of diet-induced hypercholesterolaemia by saponins from Panax notoginseng in rats.

Authors :
Wu, Jian-Hong
Leung, George Pak-Heng
Kwan, Yiu-Wa
Sham, Tung-Ting
Tang, Jing-Yi
Wang, You-Hua
Wan, Jian-Bo
Lee, Simon Ming-Yuen
Chan, Shun-Wan
Source :
Journal of Functional Foods; Jul2013, Vol. 5 Issue 3, p1159-1169, 11p
Publication Year :
2013

Abstract

Highlights: [•] Investigate the hypocholesterolaemic and vascular protective effects of PNS. [•] 28-Day treatment of PNS improved lipid profile in hypercholesterolaemic rats. [•] PNS improved endothelium-mediated aortic relaxation. [•] PNS gave its effect by changing the hepatic CYP7A1 and PPARα expressions. [•] This study provides mechanistic explanation of PNS’s beneficial effects. [Copyright &y& Elsevier]

Details

Language :
English
ISSN :
17564646
Volume :
5
Issue :
3
Database :
Supplemental Index
Journal :
Journal of Functional Foods
Publication Type :
Academic Journal
Accession number :
89346484
Full Text :
https://doi.org/10.1016/j.jff.2013.03.013