Hematopoietic stem cell based therapy of immunosuppressive viral infection—Numerical simulations.

Abstract: In the light of recent advantages in stem cell research and gene based therapies of viral infections, we present a numerical experiment referring to hematopoietic stem cell based therapy of immunosuppressive viral infection. We use a variation of basic mathematical model for impairment of help to simulate immune impairing infection. Next, we increase virus-specific CTL production (as in therapy) in different stages of infection. Obtained results are analyzed and compared with results from recent in vivo experiment. [ABSTRACT FROM AUTHOR]