Akt-Dependent Metabolic Reprogramming Regulates Tumor Cell Histone Acetylation.

Authors :: Lee, Joyce V.
Carrer, Alessandro
Shah, Supriya
Snyder, Nathaniel W.
Shuanzeng Wei
Venneti, Sriram
Worth, Andrew J.
Zuo-Fei Yuan
Hee-Woong Lim
Shichong Liu
Jackson, Ellen
Aiello, Nicole M.
Haas, Naomi B.
Rebbeck, Timothy R.
Judkins, Alexander
Kyoung-Jae Won
Chodosh, Lewis A.
Garcia, Benjamin A.
Stanger, Ben Z.
Feldman, Michael D.
Source :: Cell Metabolism; Aug2014, Vol. 20 Issue 2, p306-319, 14p
Publication Year :: 2014
Abstract: Lee et al. show that metabolic reprogramming induced by an oncogene affects histone acetylation. Under conditions of low glucose, Akt activates the acetyl-CoA-generating enzyme ATP-citrate lyase, leading to alterations in histone acetylation marks in tumors. In vivo, oncogenic Kras or Akt expression stimulates histone acetylation changes preceding tumor development. [ABSTRACT FROM AUTHOR]