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HIV-1 Envelope gp41 Antibodies Can Originate from Terminal Ileum B Cells that Share Cross-Reactivity with Commensal Bacteria.
- Source :
- Cell Host & Microbe; Aug2014, Vol. 16 Issue 2, p215-226, 12p
- Publication Year :
- 2014
-
Abstract
- Summary Monoclonal antibodies derived from blood plasma cells of acute HIV-1-infected individuals are predominantly targeted to the HIV Env gp41 and cross-reactive with commensal bacteria. To understand this phenomenon, we examined anti-HIV responses in ileum B cells using recombinant antibody technology and probed their relationship to commensal bacteria. The dominant ileum B cell response was to Env gp41. Remarkably, a majority (82%) of the ileum anti-gp41 antibodies cross-reacted with commensal bacteria, and of those, 43% showed non-HIV-1 antigen polyreactivity. Pyrosequencing revealed shared HIV-1 antibody clonal lineages between ileum and blood. Mutated immunoglobulin G antibodies cross-reactive with both Env gp41 and microbiota could also be isolated from the ileum of HIV-1 uninfected individuals. Thus, the gp41 commensal bacterial antigen cross-reactive antibodies originate in the intestine, and the gp41 Env response in HIV-1 infection can be derived from a preinfection memory B cell pool triggered by commensal bacteria that cross-react with Env. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 19313128
- Volume :
- 16
- Issue :
- 2
- Database :
- Supplemental Index
- Journal :
- Cell Host & Microbe
- Publication Type :
- Academic Journal
- Accession number :
- 97674703
- Full Text :
- https://doi.org/10.1016/j.chom.2014.07.003