Resveratrol: influences on gene expression in human skin.

There are many phytochemicals such as polyphenols that can modulate inflammatory responses and provide protective roles against many diseases and cancers, especially with aging. Resveratrol is a polyphenolic molecule found in plant and food products with such properties. However, a comprehensive examination of resveratrol influencing human skin gene expression has not been performed. This study quantified differential gene expression/mRNA levels via gene array technology using human skin equivalent cultures with resveratrol exposure at 1.0% for 24 hours and via subsequent qPCR experiments. The results indicate that resveratrol can ameliorate the aging of human skin by significantly stimulating SIRT 1, extracellular matrix proteins, such as collagens and elastin, and antioxidants while significantly inhibiting inflammatory and dermal-aging biomarkers. Resveratrol's anti-aging protection altered specific dermal biomarkers through a variety of mechanisms to protect the skin. Thus, the results demonstrate the potential resveratrol has in human dermal applications to maintain and improve human skin health. [ABSTRACT FROM AUTHOR]