Pre-clinical Cognitive Phenotypes for Alzheimer Disease: A Latent Profile Approach.

The article makes use of the data from the National Alzheimer Disease Coordinating Center (NACC) to identify subtypes of cognitively normal adults with various cognition patterns, which may imply later Alzheimer disease (AD) or dementia onset. Findings discussed include the results of the exploratory factor analysis (EFA) performed on the first half of the sample, the latent profile analysis (LPA) done using the CFA factor scores, baseline age and sex, and the predictors of profile membership.