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I"C"l"n: A chloride channel paramount for cell volume regulation
- Source :
- The Journal of Allergy and Clinical Immunology; January 1996, Vol. 98 Issue: 5 pS98-S101, 4p
- Publication Year :
- 1996
-
Abstract
- Cell volume regulation is a ubiquitous cell regulatory mechanism based on meticulously controlled ion transport mechanisms. Keeping the absolute volume constant seems to be of the highest priority for most cells and is achieved at the expense of altered intracellular ion concentrations. We have been able to demonstrate that I"C"h"v a chloride channel cloned from epithelial cells, is paramount for the ability of swollen cells to regulate their volume back to that under resting conditions. A unique feature of I"C"l"n is the distinct sensitivity of these channels for nucleotides and nucleoside analogues added to the extracellular fluid. In addition, cromolyn sodium and nedocromil sodium, drugs used by patients with asthma, are able to impede the function of these channels.
Details
- Language :
- English
- ISSN :
- 00916749 and 10976825
- Volume :
- 98
- Issue :
- 5
- Database :
- Supplemental Index
- Journal :
- The Journal of Allergy and Clinical Immunology
- Publication Type :
- Periodical
- Accession number :
- ejs10292631
- Full Text :
- https://doi.org/10.1016/S0091-6749(96)80135-7