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Hirudin therapy during thrombolysis for venous thrombosis in heparin-induced thrombocytopenia
- Source :
- Vascular Medicine; November 1994, Vol. 5 Issue: 4 p239-242, 4p
- Publication Year :
- 1994
-
Abstract
- Heparin-induced thrombocytopenia (HIT) is the most common drug-related thrombocytopenia. Thromboembolic complications occur in approximately 50% of patients with HIT and result in limb amputation and death in up to 20% and 30% respectively. Because patients with a history of HIT may require future intravenous anticoagulation but have a high-risk of thromboembolism if re-challenged with heparin, alternative therapies are necessary when further anticoagulation is indicated. The use of direct thrombin inhibitors in HIT patients who also require thrombolytic therapy offers unique challenges to anticoagulant monitoring and safety. We present a case of progressive ileofemoral deep venous thrombosis in a patient with a history of HIT in order to review the combined use of hirudin and thrombolysis in this setting.
Details
- Language :
- English
- ISSN :
- 1358863X and 14770377
- Volume :
- 5
- Issue :
- 4
- Database :
- Supplemental Index
- Journal :
- Vascular Medicine
- Publication Type :
- Periodical
- Accession number :
- ejs10339927
- Full Text :
- https://doi.org/10.1177/1358836X0000500407