Synthesis of New Cyclitol Compounds That Influence the Activity of Phosphatidylinositol 4-Kinase Isoform, PI4K230

The synthesis, chemical derivatization, and investigation of the inhibitory properties of novel cyclitol derivatives on the phosphatidylinositol 4-kinase enzymes PI4K55 and PI4K230 involved in the phosphatidylinositol cycle are reported. Some of the prepared cyclitol derivatives (i.e. <BO>9</BO>, <BO>11</BO>, <BO>12</BO>, and <BO>14</BO>) proved to be very powerful and specific irreversible inhibitors of PI4K230 at or below a concentration of 1 mM.