A New Facile Synthesis and Antiviral Activity of Oxazofurin

Authors :: Franchetti, P.
Messini, L.
Cappellacci, L.
Grifantini, M.
Guarracino, P.
Marongiu, M. E.
Piras, G.
La Colla, P.
Source :: Nucleosides and Nucleotides; March 1993, Vol. 12 Issue: 3 p359-368, 10p
Publication Year :: 1993
Abstract: A new, more facile synthesis of oxazofurin, a structural analogue of tiazofurin, selenazofurin and ribavirin, has been carried out by rhodium catalyzed reaction of ethyl α-formyl-diazoacetate with 2,3, 5-tri-O-benzoyl-β-D-ribofu-ranosyl cyanide. When evaluated against DNA and RNA viruses, HIV-1 inclu-ded, oxazofurin was found inactive. It was also ineffective in potentiating the anti-HIV activity of 2', 3'-dideoxyadenosine.