Bioactive Compounds from Combretum erythrophyllum

Authors :: Schwikkard, S.
Zhou, B.-N.
Glass, T. E.
Sharp, J. L.
Mattern, M. R.
Johnson, R. K.
Kingston, D. G. I.
Source :: Journal of Natural Products; April 2000, Vol. 63 Issue: 4 p457-460, 4p
Publication Year :: 2000
Abstract: A methanol extract of Combretum erythrophyllum showed inhibitory bioactivities in a yeast-based microtiter assay for DNA-damaging agents. Bioassay-guided fractionation of this extract yielded two known bioactive compounds, combretastatin A-1 and (−)-combretastatin, and two new bioactive glucosides, combretastatin A-1 2-β-<SCP>d</SCP>-glucoside (<BO>1</BO>) and combretastatin B-1 2-β-<SCP>d</SCP>-glucoside (<BO>2</BO>). The structures of the new compounds were assigned by <SUP>1</SUP>H and <SUP>13</SUP>C NMR, DEPT, HMQC, and HMBC spectra.

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