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Review: Melanocyte Migration and Survival Controlled by SCF/c-kit Expression
- Source :
- Journal of Investigative Dermatology Symposium Proceedings; November 2001, Vol. 6 Issue: 1 p1-5, 5p
- Publication Year :
- 2001
-
Abstract
- Melanocytes are derived from neural crest and migrate along the dorsolateral pathway to colonize the final destination in the skin. Stem cell factor and its receptor c-kit were identified as gene products of Sl and W mutant loci; both of them were known to have defects in melanocytes survival. In this review, we focus on the function of stem cell factor and c-kit in melanocyte migration and survival, which has become clearer in the last decade. By analysis of both molecules in wild-type and white spotting mutant mice, ligand and receptor set were shown to play multiple roles in the development of melanocytes in mouse ontogeny. Functional blockade of c-kit by specific monoclonal antibody illustrated distinct c-kit dependent and independent stages in melanocyte development. Finally, SCF transgene expression demonstrated that part of the c-kit dependent step is regulated by spatiotemporally specific ligand expression and also indicated the presence of c-kit independent melanocyte stem cells in postnatal skin.Journal of Investigative Dermatology Symposium Proceedings (2001) 6, 1–5; doi:10.1046/j.0022-202x.2001.00006.x
Details
- Language :
- English
- ISSN :
- 10870024 and 15291774
- Volume :
- 6
- Issue :
- 1
- Database :
- Supplemental Index
- Journal :
- Journal of Investigative Dermatology Symposium Proceedings
- Publication Type :
- Periodical
- Accession number :
- ejs11954953
- Full Text :
- https://doi.org/10.1046/j.0022-202x.2001.00006.x