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Verification of Self-Report of Zygosity Determined via DNA Testing in a Subset of the NAS-NRC Twin Registry 40 Years Later
- Source :
- Twin Research and Human Genetics; August 2005, Vol. 8 Issue: 4 p362-367, 6p
- Publication Year :
- 2005
-
Abstract
- AbstractThe National Academy of Sciences ? National Research Council (NAS-NRC) twin panel, created nearly 50 years ago, had twin zygosity determined primarily via a similarity questionnaire that has been estimated to correctly classify at least 95% of twins. In the course of a study on the genetics of healthy ageing in the NAS-NRC twins, DNA was collected for genome-wide scanning and zygosity confirmation was examined in 343 participating pairs. The sample was supplemented from two other studies using NAS-NRC twins where one or both co-twins were suspected to have Alzheimer disease or another dementia, or Parkinson's disease. Overall 578 twin pairs with DNA were analyzed. Zygosity assignment for 96.8% (519/536) was confirmed via questionnaire. Among 42 pairs whose questionnaire responses were inconclusive for assigning zygosity, 50% were found to be monozygous (MZ) and 50% were dizygous (DZ). There was some evidence for greater misclassification of presumed DZ pairs in the healthy ageing study where participation favored pairs who were similar in having a favorable health history and willingness to volunteer without any element of perceived risk for a specific disease influencing participation.
Details
- Language :
- English
- ISSN :
- 18324274
- Volume :
- 8
- Issue :
- 4
- Database :
- Supplemental Index
- Journal :
- Twin Research and Human Genetics
- Publication Type :
- Periodical
- Accession number :
- ejs12395819
- Full Text :
- https://doi.org/10.1375/twin.8.4.362