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Itai-itai disease is not associated with polymorphisms of the estrogen receptor α gene
- Source :
- Archives of Toxicology; December 1999, Vol. 73 Issue: 8-9 p496-498, 3p
- Publication Year :
- 1999
-
Abstract
- Abstract: Itai-itai (or ouch-ouch) disease is a syndrome accompanied by bone mineral disorders, and which may be related to oral cadmium exposure. Itai-itai predominantly affects postmenopausal women with a history of multiple childbirths. Recently, it has been reported that polymorphisms of the estrogen receptor α (ERα) gene are associated with postmenopausal reduction of bone mineral density in Japanese women. However, estrogen receptors have never been studied in itai-itai disease. In this study, we examined the genotypic distributions of PvuII and XbaI restriction fragment length polymorphisms (RFLPs) of the ERα gene in patients with itai-itai disease and compared them with those of control subjects. The RFLPs are represented here as Pp (PvuII) and Xx (XbaI); the capital and small letters signify the absence and presence of restriction sites, respectively. The genotypic distributions of the patient group were: PP, 14.8%; Pp, 55.6%; pp, 29.6%; XX, 7.4%; Xx, 29.6%; and xx, 63.0%. These distributions were similar to those observed for the control groups, hence no pattern of genotypic distribution was observed that could be related to itai-itai disease. We conclude that RFLPs of the ERα gene may not be associated with itai-itai disease.
Details
- Language :
- English
- ISSN :
- 03405761 and 14320738
- Volume :
- 73
- Issue :
- 8-9
- Database :
- Supplemental Index
- Journal :
- Archives of Toxicology
- Publication Type :
- Periodical
- Accession number :
- ejs1239894
- Full Text :
- https://doi.org/10.1007/s002040050642