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Host immunosurveillance contributes to the control of erbB-2 overexpression in HLA-A2-breast-cancer patients
- Source :
- International Journal of Cancer; 22 December 1999, Vol. 84 Issue: 6 p598-603, 6p
- Publication Year :
- 1999
-
Abstract
- Overexpression of gp185<SUP>erbB-2</SUP> has been associated with reduced survival in breast-cancer patients. Our earlier results, now confirmed in a larger cohort of patients (798), evidenced that the HLA-A2 allele may participate in the modulation of the erbB-2 tumor phenotype in vivo. In the present study, we evaluated other clinico-biopathologic parameters possibly involved in the host immune response against erbB-2. Localization of the CD3<SUP>+</SUP> T-cell infiltrate was taken into consideration in 705 primary breast tumors, and expression of HLA-class-I and HLA-A2 antigens was evaluated in a subgroup of 170 frozen primary tumors of HLA-A2-positive patients. The presence or the absence of HLA-class-I and HLA-A2 antigens in primary tumors did not correlate with erbB-2 expression. However, HLA-A2-positive tumors preferentially showed intratumoral lymphocyte localization, whereas the lesions displaying undetectable HLA-class-I expression showed peritumoral CD3<SUP>+</SUP> T-cell localization. Taking into account erbB-2 immunoreactivity, we found that the relationship between HLA-A2 expression and intratumoral CD3<SUP>+</SUP> T-lymphocyte localization is significant only in the erbB-2 negative subset, whereas the relationship between lack of HLA-class-I expression and peritumoral CD3<SUP>+</SUP> T-lymphocyte localization is significant only in the erbB-2-positive subset. These data provide novel in vivo evidence of the possible contribution of the host immune system to control of erbB-2 oncogene overexpression in breast cancer. Int. J. Cancer (Pred. Oncol.) 84:598603, 1999. © 1999 Wiley-Liss, Inc.
Details
- Language :
- English
- ISSN :
- 00207136 and 10970215
- Volume :
- 84
- Issue :
- 6
- Database :
- Supplemental Index
- Journal :
- International Journal of Cancer
- Publication Type :
- Periodical
- Accession number :
- ejs1287319
- Full Text :
- https://doi.org/10.1002/(SICI)1097-0215(19991222)84:6<598::AID-IJC10>3.0.CO;2-7