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N-ras Mutations in Acute Myelogenous Leukemia: A Review of the Current Literature and an update of the Southwest Oncology Group Experience

N-ras Mutations in Acute Myelogenous Leukemia: A Review of the Current Literature and an update of the Southwest Oncology Group Experience

Authors :
Radich, J. P.
Kopecky, K. J.
Appelbaum, F.
Willman, C. L.
Collins, S. J.
Source :
Leukemia & Lymphoma; 1992, Vol. 6 Issue: 4-5 p325-334, 10p
Publication Year :
1992

Abstract

Point mutations of the N-ras proto-oncogene have been frequently detected in samples of acute myelogenous leukemia (AML). In general the N-ras point mutation has been found in approximately 25% of samples, with some studies detecting the mutation in as many of 60% of samples. In this report we review the current literature regarding N-ras mutations in AML with emphasis on the updated experience of the Southwest Oncology Group (SWOG). The SWOG study examined 55 adult AML patients prospectively enrolled in a treatment protocol and found N-ras point mutations in 8 of 55 patients (15%). These mutations were usually in codon 12, 13 or 61, but one patient had mutations in both codons 13 and 61, and another had an unusual point mutation in N-ras codon 60. The presence of the N-ras mutation was not associated with pre-treatment clinical variables, response to induction therapy, or survival, except for a higher percentage of FAB M4 subtypes among mutation-positive patients. In this paper we compare the SWOG experience to the aggregate of literature regarding N-ras mutations in AML. In general while the N-ras mutation is common in AML, there is no clear evidence that it is sufficient or necessary for leukemic transformation. The presence of the N-ras mutation in AML does not seem to identify a unique clinical subset of AML patients.

Details

Language :
English
ISSN :
10428194 and 10292403
Volume :
6
Issue :
4-5
Database :
Supplemental Index
Journal :
Leukemia & Lymphoma
Publication Type :
Periodical
Accession number :
ejs13114329
Full Text :
https://doi.org/10.3109/10428199209053564