Anticholinergic Reduction of Prolonged 'Maximal' Histalog-stimulated Gastric Secretion in Man

A method is described by which the acid secretion of the stomach is maintained at a high level for 11 hours by repeated large doses of histalog subcutaneously injected. In this investigation, two groups of cases, with one untreated, the other treated, with a perorally administered anti-cholinergic, it was possible to study the duration of the drug. The anticholinergic investigated was oxyphencyclimine HCl (Daricol®). The mean duration of 10 mg (1 tablet) was in 8 duodenal ulcer patients at least 6 hours, and of 20 mg (2 tablets) given to 5 duodenal ulcer patients at least 11 hours. The long duration of both 10 mg and 20 mg of oxyphencyclimine should facilitate the adjustment of the optimal effective dose (OED), which might be important in the treatment of hypersecretion in cases of duodenal ulcer.