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Murine osteoblastlike cells and the osteogenic cell MC3T3-E1 release a macrophage colony-stimulating activity in culture
- Source :
- Calcified Tissue International; September 1987, Vol. 41 Issue: 3 p151-156, 6p
- Publication Year :
- 1987
-
Abstract
- Summary: The osteoclast may be of hematopoietic lineage and as such its development could be regulated by colony-stimulating factors. Since there is much interest as to whether osteoblasts influence bone resorption, we examined whether bone cells produce colony-stimulating activity. Both cells isolated from neonatal calvaria and the osteogenic cell MC3T3-E1 were found to constitutively release a colony-stimulating activity possessing characteristics of a macrophage colony-stimulating factor, as determined by basic biochemical purification and by identity of colonies induced in cultures of bone marrow cells. Release could be increased by the presence of the bone-resorbing agents lipopolysaccharide and 1,25 dihydroxyvitamin D<subscript>3</subscript>. We conclude that the osteoblast may contribute to both the processes of osteoclast formation and of hematopoiesis through the secretion of colony-stimulating activity into the adjacent bone marrow.
Details
- Language :
- English
- ISSN :
- 0171967X and 14320827
- Volume :
- 41
- Issue :
- 3
- Database :
- Supplemental Index
- Journal :
- Calcified Tissue International
- Publication Type :
- Periodical
- Accession number :
- ejs15547985
- Full Text :
- https://doi.org/10.1007/BF02563795