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Actinoplanic acids A and B as novel inhibitors of farnesyl-protein transferase
- Source :
- Applied Microbiology and Biotechnology; 19950801, Vol. 43 Issue: 4 p610-616, 7p
- Publication Year :
- 1995
-
Abstract
- Actinoplanic acids A and B are macrocyclic polycarboxylic acids that are potent reversible inhibitors of farnesyl-protein transferase. Actinoplanic acids A and B were isolated from Actinoplanes sp. MA 7066 while actinoplanic acid B was isolated from both MA 7066 and Streptomycessp. MA 7099. Actinoplanic acids A and B are competitive with respect to farnesyl diphosphate and are selective inhibitors of farnesyl-protein transferase because they do not inhibit geranylgeranyl-protein transferase type 1 or squalene synthase. MA 7066 is believed to be a novel species of actinomycetes while MA 7099 is believed to be a novel strain of Streptomyces violaceusnigeron the basis of morphological, biochemical and chemotaxonomic characteristics as well as its production of actinoplanic acids.
Details
- Language :
- English
- ISSN :
- 01757598 and 14320614
- Volume :
- 43
- Issue :
- 4
- Database :
- Supplemental Index
- Journal :
- Applied Microbiology and Biotechnology
- Publication Type :
- Periodical
- Accession number :
- ejs15713790
- Full Text :
- https://doi.org/10.1007/s002530050459