Dimethylsulfoxyd — ein neues ototoxisches pharmakum

50%-DMSO-solution effects the following damage to the acoustic biopotentials (cochlear microphonics; excitation and adaptation of the compound action potentials of the acoustic nerve) of the cat:1.After application of DMSO into the external auditory meatus during 21 days:a)diminution of the threshold shift of 20 dB;b)severe damage to the outer hair cells of 65%;c)medium damage to the inner hair cells of 30%;d)disturbance of the metabolism of adaptation;e)severe damage to the hair cells of the basal turn of the cochlea.2.Acute 500/0-DMSO-damage:a)application into the external auditory meatus effects a damage to the compound action potentials of the acoustic nerve of 40% (during 6 hours);b)application into the middle-ear effects a damage to the compound action potentials of the acoustic nerve of 60% (during 6 hours).