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A negative inotropic effect of acetylcholine in the presence of several phosphodiesterase inhibitors
- Source :
- Experientia; July 1981, Vol. 37 Issue: 7 p755-756, 2p
- Publication Year :
- 1981
-
Abstract
- The phosphodiesterase inhibitors papaverine, theophylline and 3-isobutyl-1-methylxanthine (IBMX) reveal a negative inotropic effect of acetylcholine in cat ventricular heart muscle. This effect is unrelated to β-adrenoceptor stimulation and possibly mediated by the accumulation of cyclic GMP.
Details
- Language :
- English
- ISSN :
- 00144754
- Volume :
- 37
- Issue :
- 7
- Database :
- Supplemental Index
- Journal :
- Experientia
- Publication Type :
- Periodical
- Accession number :
- ejs16524268
- Full Text :
- https://doi.org/10.1007/BF01967963