On the role of planar chirality: a tunable enantioselectivity in palladium-catalyzed allylic alkylation with planar chiral 1,1'-P,N-ferrocene ligands

A series of planar chiral 1,1'-P,N-2'-substituted ferrocene ligands 9–12 and 16, prepared with diastereopurity >99∶1, have been used to examine the role of planar chirality, and significant effects on enantioselectivity as well as the control of absolute configuration in palladium-catalyzed allylic alkylation as a model reaction were observed.