Unprecedented Consecutive, Competitive Nucleophilic Addition to Construct Densely Functionalized Propargylic Alcohols

Two for the price of one: A new tandem reaction involving two consecutive, competitive nucleophilic additions was developed to construct a series of densely functionalized propargylic alcohol derivatives from simple materials without functional protection, in which a variety of electrophiles including cyclopropanone and aromatic aldehydes have been successfully employed. Multiple functionalities in products 1and 2make them versatile structural motifs for further elaboration.