Inhibition of giant cell formation by compound 48/80 after infection with herpesvirus hominis

Summary Tritium-labelled Compound 48/80 is strongly bound by herpesvirus-infected and noninfected cells. Its potency to inhibit lecithine-biosynthesis decreases in time, despite it remains bound to cells. Cpd 48/80 and the dimer have proven to be inhibitors of choline kinase (E.C.2.7.1.32). This effect is small with respect to its potency of overall inhibition of lecithine-biosynthesis. Therefore, it is assumed that it inhibits further the choline transport through the membranes.