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Identification of solvents of abuse using gas chromatography/Fourier transform infrared spectrometry after headspace sampling

Authors :
Deveaux, M.
Huvenne, J.
Source :
Chromatographia; September 1987, Vol. 23 Issue: 9 p626-630, 5p
Publication Year :
1987

Abstract

Summary: After experimental intoxication of rats, gas chromatography — Fourier transform infrared spectrometry with headspace sampling (HS/GC/FT-IR) was used to identify solvents of abuse in biological material (blood, liver, lungs and brain). Limits of detection were measured for acetone, 2-butanone, ether, toluene and trichlorethylene with standard solutions. All the solvents have been identified in the organs of the intoxicated rats. For blood samples a salting-out effect was obtained with potassium carbonate. HS/GC/FT-IR allowed the identification of metabolites of acetone (isopropanol) and of 2-butanone (2-butanol) in blood and organs.

Details

Language :
English
ISSN :
00095893 and 16121112
Volume :
23
Issue :
9
Database :
Supplemental Index
Journal :
Chromatographia
Publication Type :
Periodical
Accession number :
ejs17139665
Full Text :
https://doi.org/10.1007/BF02311489