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Hypermutation in stationary-phaseE. coli: tales from thelacoperon
- Source :
- Journal of Genetics; April 1999, Vol. 78 Issue: 1 p13-20, 8p
- Publication Year :
- 1999
-
Abstract
- Escherichia colicells are capable of complex regulatory responses to environmental conditions and stresses. In some circumstances, the response includes an increase in the mutation rate, effectively mutagenizing the genome. The classic example is the SOS response to DNA damage. Recent work indicates that other environmental stresses can also result in mutation of the genome. Modulation of mutation rate may be a more prevalent stress response than previously thought. In this review we focus on genome-wide mutation inE. colicells subjected to a nonlethal genetic selection for reversion of alacframeshift allele. Reversion of thelacframeshift allele occurs via a novel mechanism that requires homologous recombination functions, and is enhanced by transiently diminished postsynthesis mismatch repair. A model for recombination-dependent stationary-phase mutation will be presented and its relevance for genome-wide mutation discussed.
Details
- Language :
- English
- ISSN :
- 00221333 and 09737731
- Volume :
- 78
- Issue :
- 1
- Database :
- Supplemental Index
- Journal :
- Journal of Genetics
- Publication Type :
- Periodical
- Accession number :
- ejs17488585
- Full Text :
- https://doi.org/10.1007/BF02994698