Back to Search
Start Over
The plexin-B1/Rac interaction inhibits PAK activation and enhances Sema4D ligand binding.
- Source :
- Genes & Development; April 2002, Vol. 16 Issue: 7 p836-845, 10p
- Publication Year :
- 2002
-
Abstract
- The small GTPase Rac has been implicated in growth cone guidance mediated by semaphorins and their receptors. Here we demonstrate that plexin-B1, a receptor for Semaphorin4D (Sema4D), and p21-activated kinase (PAK) can compete for the interaction with active Rac and plexin-B1 can inhibit Rac-induced PAK activation. We have also demonstrated that expression of active Rac enhances the ability of plexin-B1 to interact with Sema4D. Active Rac stimulates the localization of plexin-B1 to the cell surface. The enhancement in Sema4D binding depends on the ability of Rac to bind plexin-B1. These observations support a model where signaling between Rac and plexin-B1 is bidirectional; Rac modulates plexin-B1 activity and plexin-B1 modulates Rac function.
Details
- Language :
- English
- ISSN :
- 08909369 and 15495477
- Volume :
- 16
- Issue :
- 7
- Database :
- Supplemental Index
- Journal :
- Genes & Development
- Publication Type :
- Periodical
- Accession number :
- ejs18938468
- Full Text :
- https://doi.org/10.1101/gad.966402